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ʱ䣺2018-05-02 Ը ҪͶ

ȡʹҩ忹ҩ(NSAID)һнȡʹסʪö̴ṹҩһִҵҩʦҩѧרҵ֪ʶѡ㣬Ҹϰ

ڶ ȡʹҩʹҩ

һ ȡʹҩ

ȡʹҩ忹ҩ(NSAID)һнȡʹסʪö̴ṹҩͨƺϳǰĻøͬҩá

һҩٴ

(һ)ص

NSAID Ҫ֢ͨϸĻϩлһø(COX)֢ʣӶǰغѪ˨صĺϳɡ

COX ͬøCOX-1 COX-2֢ӦҪ COX-2֯θڡѪС COX-1 ĴڣάӦٵĹܣá

忹ҩ仯ѧṹûƿɷΪˮࡢࡢͪࡢࡢࡢ12-ࡢѡ COX-2 Ƽ()

1.ˮ

ҩ˾ƥ֡ŵ

2.

ҩӡ

3.

ҩ˫ȷᡢͪȡ

4.

ҩҡ

5.12-

ҩֳ࣬ҩ COX-2 ñȶ COX-1 ǿһѡԡҩ

6.ѡ COX-2 Ƽ

ҩп

()ͲӦ

NSAID θӦΪCOX-2 ѡƼɱθ𺦣ѪܲӦա

()֤()

1.PڸŮ12 ¶ͯ

2.Ѫ߽ð˾ƥ;ѪҺϵͳ쳣ظ쳣Ĺ쳣߽;ضȸ߽

3.ѪѲѪС֢߽ð˾ƥ;ļʷвʷ߽

()ҩ໥

1.˾ƥ NSAID ʱЧǿɽ NSAID ҩöȣθð񡢳ѪȷӣѪСۼǿλѪķա

2.ӳڴ밢˾ƥ֡ˮƼ NSAID ҩʱԣͷװȡ

3.ҩͪء㶹صȿѪҩѪСҩÿӳѪա

4.NSAID ҩӦ㹻ˮ֣ƿʼǰӦܣ⼱˥ߡ

5.NSAID ҩѪܽآϼС˹ЭͬãӰʱ֢״ء

6.ͨǰؽ鵼ãNSAID ҩӻصԡںڼҪⶨܡ껼Ҫϸܡ

7.NSAID ҩκãɼйѪŨȣܻﵽԵŨȡ

ҩ໤(Ҫ)

(һ)Ȩ忹ҩĻͳѪķ

(1)Ӧ廯;ֻһ NSAID ҩʹ l2 ܺЧŸΪһ֡

(2)ֻ NSAID ҩͬʱãЧӣӦࡣ

(3)Ҵ³ѪͳѪʱӳҩڼӦ;

()ע NSAID ҩDZڵѪܷ

NSAID ҩDZڵѪܲ¼գಡʷ߾ѡС

()עҩǰӦ

ҩǰҩṹԻǰҩйʷߺá

ҪҩƷ

Ӧ֤Сضȷ;ᡢжʹͷʹʹʹؽʹʹȡΪжȹԹؽ׵ѡҩ

ע

(1)β߾ⳤʹá

(2)ܲȫ߳ڴʹñƷԵΣգʽʹá

(3)ڴҩӦڼܺѪ

Indometacin

Ӧ֤ڻᡢлضȷʪ֢ʹԹˣʹԹؽףʹȵʹڸȵĶ֢ȡ

ע(1) Խ᳦׼ʷá (2)ɭ;񼲲ߣʹúʹء

˫ȷ

Ӧ֤ڸּԹؽ׺֯ʪµʹԼ˺ʹʹͷʹȡԳ˼ͯķнá˫ȷЧѸ٣ʹֹʹ

ע(1)ƷθѪķղˮѪѹߡ

(2)θʷ߱ʹá

lbuprofen

Ӧ֤ڻԹؽ׵Ĺؽʹ֢״

ע԰˾ƥֻ忹ҩ߶ԱƷнӦ

Nimesulide

Ӧ֤Թؽ;ͼԴ˺ʹ;ʲ֢ʹ;ʹ;ϺȾķȵ֢״

ע(1)˺жܲȫʹñƷʱԽϺãӦע۲졣

(2)θѪʷá

(3)ļʷá

ڶ ʹҩ

ʹѪ߼νᾧڹؽں֯һۺ

һҩٴ

(һ)ص

ʹҩûƷΪ

(1)ϸѡԿʹԹؽҩ

(2)ҩ

(3)ٽйҩ

(4)ٽֽҩ

1.ѡԿʹԹؽҩ

ˮɼͨ

(1)ϸͰϸ

(2)֬ø A2ٵϸ԰ϸͷǰغͰϩ

(3)ƾֲϸ 1L-6 ȡ

2.ҩ

ѴΪø(XOR)ƼĿǰϳɵҩҪڣ

(1)ѴлʴƻøֹλʺͻʴлΪᣬӶɣѪẬ

(2)ֹγɽᾧڹؽڼ֯ڣʹ综֯ᾧܽ⡣

3.ٽйҩ

ҩ桢¡

4.ٽֽҩ

ûзֽøԴø;Ҷøɴٽֽ⣬תΪһܽԸõأǶԿʹһ;